Receptor Activator of NK-κB for Tumor Cells

Receptor Activator of NK-ÃŽ ºB for Tumor Cells Presentation Malignancies figure among the main sources of death around the world, representing 8.2 million passings in 2012 .Lung, liver, stomach, colorectal and bosom diseases cause the most disease passings every year. It is normal that yearly malignancy cases will ascend from 14 million out of 2012 to 22 inside the following two decades In the course of recent years, proteolytic cleavage and arrival of the ectodomain of film bound proteins, additionally alluded to as ectodomain shedding, has risen as a significant posttranslational administrative component for altering the capacity of cell surface proteins. The cleavage of RANK should diminish its accessibility on osteoclasts and their forerunners and at the same time create dissolvable distraction receptors that may hinder the RANKLâ€RANK affiliation and their by NFkB signaling[27] It was recently shown that tumor cells express RANK and actuate RANKL-RANK pathway. The RANK/RANKL hub rises as a key controller of bosom malignancy commencement, movement and metastasis. Likewise, RANKL can shield bosom malignancy cells from apoptosis in light of DNA harm, just as control the self-recharging and harbor autonomous development of tumor starting cells [13]. In an ongoing report it’s showed that NK-ÃŽ ºB Signaling could be hindered by Enterokinase by cleavage of RANK (Receptor Activator of NK-ÃŽ ºB), recommends its conceivable application in rewarding illnesses like Osteoporosis, malignant growth and maladies related with bone misfortune [14]. Enterospeptidase could explicitly separate RANK on the arrangement NEEDK was shown by a proxy peptide blocking examine [28] Enteropeptidase All creatures need to process exogenous macromolecules without pulverizing comparable endogenous constituents. The guideline of stomach related compounds is, in this manner, a crucial necessity. Vertebrates have tackled this issue, to a limited extent, by utilizing a two-advance enzymatic course to change over pancreatic zymogens to dynamic proteins in the lumen of the gut. Enteropeptidase (equivalent: enterokinase [E.C.3.4.21.9]) is aglycoprotein enzymeof the stomach related tract was found, by N. P. Schepovalnikow in 1899 in Russia (Walther 1900), as a component that is available in the duodenum and which can equipped for actuating pancreatic juice to process fibrin. Enteropeptidase changes over trypsinogen (a zymogen) convert into its dynamic structure trypsin by enteropeptidase, with specific cleavage of 6-Lys-|-Ile-7 bond which causes ensuing actuation of stomach related proteins in pancreatic emissions. Resulting actuation of trypsin,it cuts and initiates different zymogens in pancreatic secretions,including chymotrypsinogen, proelastase, procarboxypeptidases, and some prolipases [1] In practically all vertebrate species, a short trypsinogen actuation peptide is discharged that ends with the succession Asp-Asp-Asp-Asp-Lys(DDDK) (2). aside from the comparative groupings of trypsinogens from lungfish (IEEDK and LEDDK) and African ripped at frog (FDDDK). The one of a kind enteropeptidase substrate explicitness has been misused in protein building. The enteropepetidase perceiving arrangement DDDDKâ†I is frequently utilized in recombinant proteins that require explicit cleavage.Enteropeptidases particularity for its perceiving succession makes it a perfect device in biochemical applications; following protein refinement enteropeptidase can sever a combination protein containing a C-terminal tag, (for example, poly-His) connected by this grouping to get the objective protein 1.1 Enteropeptidase 1.1.1 Enteropeptidase articulation: Enterokinase is accepted to be Exclusively delivered in the brush fringe by enterocytes and flagon cells of the duodenal mucosa, the enteropeptidase is pervasively dispersed among vertebrates (Eggermont et al., 1971a,b; Rinderknecht, 1986; Mithoshi et al., 1990). It emitted in to the small digestive system. It needs graves however discovered substantialiy in villous enterocytes and maximal in the upper portion of the villi, partucilarly on the brush fringe. enteropeptidaseis emitted from organs following the passage of gulped food going from the intestin. It opposes devastation from the different catalysts in the small digestive system however is decimated by microscopic organisms in the internal organ. It has been cleaned from a few sources including porcine (Barrati et al., 1973), ox-like (Anderson et al.; Liepnieks and Light, 1979), human (Kitamoto et al., 1995), murine (Yang et al., 1998) and rodent digestive system (Yahagi et al., 1996). In all cases the protease is by all accounts communicated as a solitary chain antecedent, which must be cut to accomplish the local disulfide-connected heterodimer, on account of human enteropeptidase comprising of a 86 kDa substantial chain and a 28 kDa light chain. The majority of the basic components are profoundly moderated, particularly between human, cow-like and porcine enteropeptidase, which share more than 80% character in their amino corrosive arrangements. The substantial chain, which contains different areas including membranespanning hydrophobic film stays, a few receptorlike themes and up to 10 intramolecular disulfide spans, is answerable for explicit macromolecular substrate acknowledgment (Lu et al., 1997; Mikhailova et al., 2007). The light chain is associated with the overwhelming chain by means of one disulfide e connect and contains the old style reactant set of three (His57, Asp102 and Ser195 in chymotrypsin numbering) with up to four intramolecularâ disulfide spans. The little and chemically dynamic light chain offers particularly high potential for biotechnological applications, and a few endeavors to comprehend and improve the usefulness of this protease have been made (Lu et al., 1999; Liew et al., 2007; Shahravan et al., 2008). et al., 2004), Lu et al. (1997) have decided the precious stone structure of an ox-like light chain complex with a trypsinogen enactment peptide simple at a goals of 2.3 A  ° . Human enteropeptidase has been recombinantly communicated in E.coli by Gasparian et al. (2003), in spite of the fact that this brought about insoluble totals and no precious stone structure has yet been accounted for. The ensuing refolding by means of 6 M guanidinium chloride brought about an absolute refolding yield of 2% after two patterns of renaturation. Enteropeptidase is serine protease it’s a heterodimer of a multidomain substantial chain and a reactant light steel by a disulfide bond . Enteropeptidase tied down to intestinal brush outskirt of duodenal enterocytes by a transmem brane fragment in the a 82â€140 kDa substantial chain and a 35â€62 kDa light chain which comprise the reactant subunit. Substitution of the transmembrane area by a cleavable sign peptide doesn't hinder trypsinogen actuation, showing that layer affiliation is notâ required for substrate acknowledgment (Lu et al., 1997)..[3]Enteropeptidase is a piece of theâ chymotrypsin-gathering of serine proteases, and is fundamentally take after to these proteins.[4] 1.1.2. Enteropeptidase quality cosmology: In people, PRSS7 quality (otherwise called ENTK) encodes enteropeptidase protein on chromosome 21q21. The quality ranges ~90-kb long and has 25 exons .Enteropeptidase mRNA is communicated significantly in the duodenum and, at poor levels, in the proximal area of jejunum. The human enteropeptidase cDNA open perusing casing of encodes a 1019 amino acids Type II transmembrane protein with a determined mass of 113kDa and with especially 17 potential N-connected glycosylation destinations. Few frameshift and drivel transformations in this quality lead to an uncommon latent condition portrayed by serious inability to flourish in influenced infants, due to enteropeptidase deficiency.[6] Conversely, duodenopancreatic reflux of proteolytically dynamic enteropeptidase may cause intense and interminable pancreatitis. 1.1.4 Structure Ox-like enteropeptidase is orchestrated as a solitary chain antecedent of 1035 amino corrosive buildups (5) that seems to require proteolytic initiation, recommending that enteropeptidase may not be the â€Å"first† protease of the stomach related hydrolase course. Dynamic enteropeptidase has been cut after Arg-800 to deliver a disulfide-connected heterodimer with an amino-terminal 120-kDa overwhelming chain and a 47-kDa light chain; 40% of the genuine mass of these polypeptides is because of glycosylation (6, 7). The reasoned amino corrosive groupings proposed that from a solitary chain forerunner, dynamic two-chain enteropepetidase is determined. A potential sigal-stay (SA) grouping close to the amino end intercedes film relationship of enter peptidase in digestive tract. The amino-terminal substantial chain comprise the spaces that are homologous to areas of the low thickness lipoprotein receptor(LDLR), two rehashes found in supplement serine proteases C1r and C1s, a MAM space (so named for comparative themes initially recognized in the metalloprotease meprin, the Xenopus laevis neuronal acknowledgment proteinA5, and protein-tyrosine phosphatase Mu), and a macrophage forager receptor cysteine-rich rehash ( MSCR). The light chain is an average chymotrypsin-like serine protease. The enactment cleavage site between the overwhelming and light chains has the arrangement Val-Ser-Pro-Lys2Ile, which may be perceived by trypsin or other trypsin-like proteases. The carboxyl-terminal reactant light ch ain is homologous to the class of trypsin-like serine proteases. Along these lines, enteropeptidase is a mosaic protein with a complex developmental history. The enteropeptidase light chain amino corrosive grouping encompassing the amino end is ITPK-IVGG (human) or VSPK-IVGG (ox-like), supporting that unidentified trypsin-like protease that severs Lys-fle attach to initiate single-chain enteropeptidase.Therefore, enterokinase may not be the principal catalyst of the course of intestinal stomach related hydrolases. Enteropeptidase particularity for the DDDDK-I arrangement of trpsinogen might be portrayed by correlative fundamental amino corrosive deposits gathered in potential S2-S5 subsites. 1.1.3 enterokinase lack In this way, enterokinase has been perceived to assume a key job in controlling intestinal prote

Achebes view of the missionaries in Things Fall Apart by Chinua Achebe.

Achebes perspective on the evangelists in Things Fall Apart by Chinua Achebe. Things Fall Apart, by Chinua Achebe, is an anecdote about a Nigerian Igbo clan compelled to suffer, and live with European Christians. These Europeans were colonizing Africa with the goals of setting up Christian teachers. While their goals were authentic, their essence was crushing to the Ibo culture. Achebe didn't care for how the Europeans and the Igbo individuals associated with one another. The European evangelists saw their religion as better than the Igbo religion in light of the fact that there was never an exertion made by them to comprehend the Ibo religion.English: Chinua Achebe talking at Asbury Hall, Bu...The teachers' objective was to come to Nigeria and assume responsibility for the Igbo society. With the end goal for them to do this, they needed to prevail upon the individuals and for them to do that; they changed over the Igbo individuals to Christianity. Achebe didn't concur with the ministers and in his story, he attempted to get the peruser to underscore with the Igbo culture. In the story, he portrays each reason and reason for each activity the Igbo individuals did. He discussed their celebrations and their customs. He even utilized words like obi and egwugwu as an approach to associate the peruser with the Igbo language.Achebe loathed what the preachers did and how they attempted to colonize his kin. I think the narrative of a man who executed a courier and hanged himself makes an intriguing perusing. The demise of Okonkwo is emblematic and Achebe parts of the bargains this to show the peruser how the Europeans saw the Igbo individuals. Okonkwo slaughtered himself in light of the fact that the Christian evangelists didn't comprehend their religion and all they needed to do was to separate their strict gatherings and convert individuals to Christianity. Achebe felt like if the Christian teachers found out about the Igbo individuals, they may...

5 Tips to Deal With a Change in 529 Plan Advisers

When you sign up for a 529 plan, one of the most important issues is selecting the best investments for your child. But if your state changes investment advisers, which many have, you may want to re-allocate your invested funds because your college savings plan will automatically place them into similar, but not identical, funds. Since the beginning of 2010, three states -- Nebraska, Ohio and Montana -- have made plans to change the investment adviser for their plans. A 529 plan investment adviser manages the investments that are offered through the college savings plan, which are usually mutual funds. When a new 529 plan investment adviser takes over, the investment funds in which you are currently invested are replaced with other, similar investment funds, says Joe Hurley, founder of Savingforcollege.com. It is all done automatically for you when the new investment adviser takes over," he says. "The new investment adviser comes up with a menu of investment options so that every option under the old plan has an equivalent option under the new plan." Generally, state treasurers who run 529 plans don't make decisions to change investment managers lightly. They may be displeased with the performance of the investment funds in the college savings plan or are looking for lower fees, Hurley says. You're given similar investments While the 529 plan does its best to put you in options that are as similar as possible to your old options, they aren't exactly the same. So, it makes sense to review what your new investments are, compare them to your old investments and decide if they still fit, says Kevin Worthley, a Certified Financial Planner with Retirement Planning Co. of New England in Providence, R.I. Any change in your investments that results from a change in investment advisers doesn't count towards the one investment change the IRS allows you to make per year, says Hurley. So, if you don't like your new investments, you're free to make a change without a penalty from the IRS. But be careful, Worthley advises, because if you make an impulsive change, you'll be stuck. A change in investment adviser is a good opportunity to review your overall investment allocation, Hurley says. Worthley agrees. "Things may have changed since you made your original investment choices. Your child is older and may be close enough to going to college that you want to be more conservative. By the time your child is a sophomore in high school, you want to move away from risk exposure, so it may be an opportune time to make a change," he says. How to evaluate 529 plan options When you're evaluating 529 plan options, consider these factors: Reputation of the investment companies. "How comparable is the new fund company to the old fund company?" Worthley asks. "If you're comparing, say, Fidelity to Vanguard, they aren't that different, although Vanguard has more index funds and the fees are lower." Costs. "Even if the fees are lower with the new investment manager, they still might be higher than other plans in other states," says Hurley. "Don't be afraid to go out of state if you can find a plan with significantly lower costs." Higher 529 plan costs add up, and every extra dime you pay in fees is one less dime you have to pay for college. Type of fund. While some investment companies offer more actively managed funds, other fund companies specialize in index funds, says Hurley. More 529 plans are moving to lower-cost, index-fund providers. So, if your 529 plan makes a change, you may be moving from actively managed funds to index funds, he adds. Actively managed funds are funds where the manager picks stocks or bonds according to an investment strategy, while index funds track the performance of a specific stock or bond market index. Age-based plans. Age-based 529 plans are a one-size fits all investment option. As your child gets older, the investments within the plan get more conservative. Still, there is wide variation among age-based 529 plans, says Worthley, so if you have an age-based plan, you'll want to compare the old plan with the new one to make sure it isn't more aggressive or more conservative than what you had before. State tax deduction: If you're invested in your state's 529 plan and get a tax deduction or credit and decide to move to another state's plan, you may lose that credit or deduction, says Worthley. Also, Hurley says if you take a state tax deduction and move the money out of the 529 plan, you have to declare the money you deducted as income on your state tax return. Posted August 27, 2010 When you sign up for a 529 plan, one of the most important issues is selecting the best investments for your child. But if your state changes investment advisers, which many have, you may want to re-allocate your invested funds because your college savings plan will automatically place them into similar, but not identical, funds. Since the beginning of 2010, three states -- Nebraska, Ohio and Montana -- have made plans to change the investment adviser for their plans. A 529 plan investment adviser manages the investments that are offered through the college savings plan, which are usually mutual funds. When a new 529 plan investment adviser takes over, the investment funds in which you are currently invested are replaced with other, similar investment funds, says Joe Hurley, founder of Savingforcollege.com. It is all done automatically for you when the new investment adviser takes over," he says. "The new investment adviser comes up with a menu of investment options so that every option under the old plan has an equivalent option under the new plan." Generally, state treasurers who run 529 plans don't make decisions to change investment managers lightly. They may be displeased with the performance of the investment funds in the college savings plan or are looking for lower fees, Hurley says. You're given similar investments While the 529 plan does its best to put you in options that are as similar as possible to your old options, they aren't exactly the same. So, it makes sense to review what your new investments are, compare them to your old investments and decide if they still fit, says Kevin Worthley, a Certified Financial Planner with Retirement Planning Co. of New England in Providence, R.I. Any change in your investments that results from a change in investment advisers doesn't count towards the one investment change the IRS allows you to make per year, says Hurley. So, if you don't like your new investments, you're free to make a change without a penalty from the IRS. But be careful, Worthley advises, because if you make an impulsive change, you'll be stuck. A change in investment adviser is a good opportunity to review your overall investment allocation, Hurley says. Worthley agrees. "Things may have changed since you made your original investment choices. Your child is older and may be close enough to going to college that you want to be more conservative. By the time your child is a sophomore in high school, you want to move away from risk exposure, so it may be an opportune time to make a change," he says. How to evaluate 529 plan options When you're evaluating 529 plan options, consider these factors: Reputation of the investment companies. "How comparable is the new fund company to the old fund company?" Worthley asks. "If you're comparing, say, Fidelity to Vanguard, they aren't that different, although Vanguard has more index funds and the fees are lower." Costs. "Even if the fees are lower with the new investment manager, they still might be higher than other plans in other states," says Hurley. "Don't be afraid to go out of state if you can find a plan with significantly lower costs." Higher 529 plan costs add up, and every extra dime you pay in fees is one less dime you have to pay for college. Type of fund. While some investment companies offer more actively managed funds, other fund companies specialize in index funds, says Hurley. More 529 plans are moving to lower-cost, index-fund providers. So, if your 529 plan makes a change, you may be moving from actively managed funds to index funds, he adds. Actively managed funds are funds where the manager picks stocks or bonds according to an investment strategy, while index funds track the performance of a specific stock or bond market index. Age-based plans. Age-based 529 plans are a one-size fits all investment option. As your child gets older, the investments within the plan get more conservative. Still, there is wide variation among age-based 529 plans, says Worthley, so if you have an age-based plan, you'll want to compare the old plan with the new one to make sure it isn't more aggressive or more conservative than what you had before. State tax deduction: If you're invested in your state's 529 plan and get a tax deduction or credit and decide to move to another state's plan, you may lose that credit or deduction, says Worthley. Also, Hurley says if you take a state tax deduction and move the money out of the 529 plan, you have to declare the money you deducted as income on your state tax return. Posted August 27, 2010

The Impact of Genetically Modified Foods - 1368 Words

It is not a secret that GMF-ed foods have spread out rapidly to the whole world.Genetically modified foods most commonly refers to the plants, which has been modified in the laboratory to enhance improved nutritional content and aimed traits created for human beings and animals. With progress in various types of technology, especially in genetic engineering, farmers and scientists have changed the way in which food is grown and made, raising questions about the methods, their risks and possible effects. GMFs have raised concerns over their own beneficial in that they are resistant to diseases, produces greater yields, and it improves the nutrition of foods making the people unaware about their effects..Every time we go to any grocery†¦show more content†¦Some may argue that this fish will still provide the nutrients that a normal fish provide. Even so, with many potential health hazards, GM food should be labeled so people know what they are getting. Side by side economists has also raised the serious concern about bringing the GM foods in the market,It is a costly and lengthy process. Many new plant genetic engineering technologies and GM plants is licensed, and this licensed infringement is a big concern of agribusiness. Yet, consumers are worried that patenting these new plant varieties will raise the price of seeds so high that small farmers and third world countries will not be able to afford seeds for GM crops, thus that results in widening the gap between the wealthy and the poor.Scientists didnt make these foods because they care about benefitting the world and helping the poor,In fact they made genetically modified foods because it benefits their businesses. Aside from human health and economic concern, genetically modified organisms have serious negative impacts on the environment too. One of those is the effect on pollinators. Most of the earths plants depend on insects for pollination and it is vitally crucial that agricultural activities do not disrupt this natural ecosystem. important pollinator thatShow MoreRelatedEnvironmental Impacts Of Genetically Modified Foods1401 Words   |  6 PagesFirstly, genetically modified foods stir up a lot of concern about their potential health impacts. Namely, they may be the cause of new allergens in our food supply, increase our exposure to pesticides or interfere with our health in ways that cannot be predicted yet in the long term. Indeed, GMOs may be considered a threat to health because of their allergenicity. To put it simply, genetic modification allows specific genes to be â€Å"identified, isolated, copied and introduced into other organisms†Read MoreGenetically Modified Foods And Its Impact On The Worlds Food Production1308 Words   |  6 Pages better, and in higher yields at lower prices. Genetically modified foods have been a topic of interest in the West for a while. Word has spread about how these genetically modified foods have some tie to our health and the health of the environment making Westerners skeptical of those foods. Society is heavily dependent on genetically modified foods to keep businesses growing and selling. At the same time, this need for an abundance of cheaper food causes harm to animals creating even more controversyRead MoreGenetically Modified Foods And Its Impact On The Agricultural Industry Worldwide1639 Words   |  7 Pagesprecarious because of his inability to en sure his food supply.† Throughout the history of mankind, the global food supply has become a battleground for politicians, scientists, and farmers. Genetically modified organisms, or GMOs, have been in the spotlight throughout much of the last four decades, offering a viable solution to world hunger issues. It is through genetic engineering that scientists can achieve the creation of genetically modified crops, creating new crop varieties designed to yieldRead More Are Genetically Modified Foods the Way to Go? Essay1538 Words   |  7 PagesWe are consuming genetically modified and processed foods every day. Genetically modified and process foods cover roughly 60 to 70% of our food supply. Supermarket processed food items now test positive for the presence of genetically modified ingredients. The hidden menu of these unlabeled genetically modified foods and food ingredients in the US now includes soybeans, soy oil, corn, potatoes, squash, canola oil, cotton seed oil, papaya , tomatoes, and dairy products. But genetic manipulationRead MoreGenetically Modified Foods1101 Words   |  4 Pageseveryday food and what the impact is on human health? Approximately 60-80 % of everyday food has one ingredient made from genetically modified foods. When hearing â€Å"genetically modified food† people automatically think it is only bad for health, but there is also a good impact surprisingly. The one bad thing is that people do not know what types food have been modified because there are no labels for GMO products. Even though GMOs have a bad impact on human health, it also has a good impact. FirstRead MoreEffects Of Genetically Modified Foods On Health And The Environment1550 Words   |  7 Pagesâ€Å"Myths about the dire effects of genetically modified foods on health and the environment abound, but they have not held up to scientific scrutiny. And, although many concerns have been expressed about the potential for unexpected consequences, the unexpected effects that have been observed so far have been benign† (â€Å"Nina Fedoroff†). With that being said, modified crops are not as bad as many people think. In fact, evidence has been found that genetically modified crops actually benefit the world’sRead MoreGenetically Modified Products And Natural Products1510 Words   |  7 Pagescustomer. For the purposes of this paper, genetically modified organisms can be defined as â€Å"plants or animals whose cells have been inserted with a gene from an unrelated species in order to take on specific characteristics† (Lee 2014). Currently, over 70 percent of packaged food at grocery stores has been genetically modified in some way. (Proof) Where are you getting this info from? While there has been a recent movement towards the consumption of organic food products, the government has yet to establishRead Mo reDiscussion About Genetically Modified Foods1529 Words   |  7 Pagesencourage or ban genetically modified foods Discussion about Genetically Modified Foods Outline Introduction a. The genetically modified foods are a long issue which is widely debated. b. People feel confused about their safety. I. Views a.) Magana-Gomez’s argument. b.) He argues that negative effects of GM food were identified â€Å"at molecular and microscopic levels†. c.) Curieux-Belfond CL contends that the benefits of genetically modified foods far outweighRead MorePlants Consume a Gene from a Different Organism in Genetic Modification1201 Words   |  5 PagesGenetically modified plants are plants that consume a gene from a different organism which has been inserted into the target plant. Genetically modifying plants changes the characteristics of the plant such as; adding more flavour; evolving in size and addition in nutritional values. The technologies used to process genetically modified crops are called; genetic engineering, biotechnology, gene technology and modern technology. Genetically modifying crops aims to change the fundamentals of agricultureRead MoreBiotechnology and Genetically Modified Foods Essay1030 Words   |  5 PagesBiotechnology and Genetically Modified Foods Are genetically modified foods safe? Genetically modified foods are crop plants created for human or animal consumption using molecular biological techniques. These plants have been modified to enhance certain traits like increased resistance to herbicides or improve nutritional content. This process traditionally has been done through breeding, but is not very accurate. Scientists have been

Media And The Law Enforcement Essay - 2002 Words

Media in law enforcement has been around for years. One of the biggest problems law enforcement agencies are having, is that there are several different types of media hitting the streets within short periods of time. The law enforcement agencies are having trouble keeping up with the different types of social media and the process is becoming harder to catch these criminals. Even the television media is hard to control because all the news stations fight for which station is going to get what news meaning that whichever station gets the stories out first, gets more credit. According to Randy Rue, a lieutenant for the Illinois State Police, the Media has to do with a lot of bias. A lot of the time the media will put news out there without have the facts of what happened. It seems like a big race for these media stations to be the first one to get A certain story out to the public and it could be completely wrong. One of the bigger problems today, is the law enforcement and race relat ions in the United States. The society hears about the opposite race being shot by the police for no apparent reasons. Also, according to Rue, â€Å"bias isn’t a problem with overall police officers. Some departments have problems with bias, but not as an overall.† The national media has a negative impact in law enforcement/race relationships. The news media on the television does a poor job with putting news out about the positives the police do for the community. They are heavy set on making theShow MoreRelatedSocial Media And The Law Enforcement3632 Words   |  15 Pagesgrounds between the law enforcement and the public, can help to control the situation without any party feel being cheated. Introduction Before the invention of Facebook, twitter, and many others, social media data collection was used by companies to get customers’ impression about their products. However, nowadays with modern technology the game has changed. Following the discoveries of these various social media networks, users areRead MoreMedia Vs. Law Enforcement2427 Words   |  10 Pages Media versus Law Enforcement Alfredo Bocanegra CRJU 4499: Spring 2016 Gang Lee 27 April 2016 Introduction Since the start of news coverage being exposed on the television during the early 1960s, when the Kennedy versus Nixon, the first ever presidential debate was broadcasted, there has been skepticism on the delivery of the news and whether or not the media sends the correct message that broadcasts to the nation. The media described Nixon as being sweaty and nervous whileRead MoreThe Effects Of Social Media On Law Enforcement1255 Words   |  6 PagesDaniel Cabrera ISS1120 Social Environment Professor Pauline Nogueira October 30, 2015 The Effects of Social Media on Law Enforcement Since the up-climb of social media began in 2003, law enforcement has greatly adapted to the social media network in order to better communicate with the public and to improve their protocol. Much of police work is unappreciated and unknown of. Therefore, some departments have taken it upon themselves to educate the public via social networks, such as Twitter and FacebookRead MoreMedia s Influence On Public Perception Of Law Enforcement Essay2350 Words   |  10 PagesIt is no secret that the media is able to influence the general public’s opinion on most anything. Whether the subject is fiction or non, movies, documentaries, and the news especially, are capable of swaying the public’s opinions and perceptions one way or the other. Not even the world of law enforcement is safe from the media’s purview (Barlow, M. H. and Barlow, D. E. and Chiricos T. G., 1995), as media portrayals often romanticize law enforcement as a well oiled machine that always gets the badR ead MoreEssay about Social Media is a Source for Criiminals and Law Enforcement1748 Words   |  7 PagesSocial media has become a popular tool for both criminals and law enforcement. There are a lot of different perspectives about how social media is instrumental to crime and solving crimes. On one hand, law enforcement can use social media websites such as Facebook and Twitter to find evidence about specific crimes. On the other hand, digital villains can use social media to break the law. This could include crimes as small as illegally downloading music, anywhere upwards to broadcasting the sellingRead MoreMedia s Negative Influence On Public View Of Law Enforcement1772 Words   |  8 PagesMedia s Negative Influence on Public View of Law Enforcement The two common opposing views towards police officers is a supper cop who saves the day and a violent officer who harms civilians. As a society we tend to zoom in on every blemish and mistake law enforcement makes and the media often encourages these views. In news outlets when police positively contribute to the community it usually only makes headlines for a day or two, but when a crisis occurs it receives high media coverage for weeksRead MoreMedia Coverage Of Law Enforcement Using Deadly Force On Our Citizens756 Words   |  4 PagesWe have seen an increase in media coverage of law enforcement using deadly force on our citizens. As a young male, it makes me uneasy to see these constant reminders of the system we live under which is why I chose Case 11.4. In this case, a police officer who is also a middle aged mother chases a teenage male into an abandoned warehouse. The officer, Mary Worthington, corners the suspect and then he draws a handgun from his pants. Some officers wou ld have seen this as an immediate threat to theirRead MoreThe Impact Of Media On The Public s Perception Of Law Enforcement And The Criminal Justice System1751 Words   |  8 PagesPolicing the Media: A literature review of the Role the Media Plays in the Public’s Perception of Law Enforcement and the Criminal Justice System. The role the mass media plays in the public perception of Law Enforcement and the Criminal Justice System is potentially important in relation to the viewer’s attitude and beliefs. 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Media outlets, in the forms of television, radio, or social websites, create a cynical view of police officers, which influences societal beliefs and creates negative connotations. These days, police are often stereotyped as aggressive, corrupt beings. The growing hatred for police officers widens the divide between citizens and law enforcement, causing tension and

E-Business Website Evaluation free essay sample

For each chosen website report the business name, the homepage URL and include a screens of the homepage. 2. For each chosen website, in 1-2 paragraphs, explain why the website belongs to that particular e-commerce business model. 3. For each chosen website, in 1-2 paragraphs, identify what you think is/are the principal business goal(s) of the website. 4. For each website, consider the following attributes and assess them on the following five-point semantic differential scale and, for each attribute, briefly explain why you give that rating: Very Poor Very Good 12 I Poor 3 14 I Inapplicable 15 I Good a. How does the website URL relate to the business name? B.How easily is the website found using general internet search engines (e. G. Google, Ask, AltaVista, Binge, Yahoo! )? C. Does the website give me all the organizational information a user could reasonably ARQ Eire? D. Are requirements to provide a users (personal or sensitive) information appropriate? E. We will write a custom essay sample on E-Business Website Evaluation or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page How well does the website reassure users about the security and use of their information? F. How well does the website foster user trust in the organization? G. How well does the website address legal issues associated with use of the website or engagement in transactions? H. How well does the website provide for the accessibility needs of users? I.How well does the website address the language or cultural needs of users? J. Does the website contain all the product information that a user could k. Does the website allow all the customization (user-managed features) that a user could reasonably expect? L. How well does the website personalize the experience for users? M. Does the website identify sufficient channels for user service/support? N. How easy is it to find any information on the website about the organization, their products or services? 0. How easy is the information on the website to read (I. E. Is provided information in appropriate language and with sufficient detail for most users)? P. Is the website easy to navigate (I. E. Eve through the website to find information, products, or services, and engage in transactions with the organization)? Q. How appropriate are the website aesthetics (e. G. Use of layout, colors, imagery, fonts, etc) for the target audience? R. How well does the website foster community among users? . How quickly does the website load into your browser and do all website features, links and embedded objects (e. G. Media files or applets) work as intended? T. How well does the website support different web-browsers or platforms (e. G. Mobile devices)? U. Does the website provide a sufficient range of payment options as could be reasonably expected? V. Does the website provide a sufficient range of delivery options as could be reasonably expected?

The Chartist Movement Essay Research Paper The free essay sample

The Chartist Movement Essay, Research Paper The Chartist Movement was one of rights. The workers felt they had worked hard for the rights than those of higher categories had. However, they were non reasoning for more money or more land, all they wanted was cosmopolitan right to vote. The workers believed it was clip to set the unrest, to rest. Their continued beliefs were that cosmopolitan right to vote was the best thing for public assurance and safety. In the National Petition dated 1839, the working-class opened their supplication with a powerful statement. When speaking about their current signifier of authorities they stated: ? the few have governed for the involvement of the few. ? The workers pess that the authorities has long wasted their money on selfish and unequal gentlemen, that do nil but serve their ain demands and benefits. They believed that if the authorities continued on its current path that the stableness of the throne would endanger. We will write a custom essay sample on The Chartist Movement Essay Research Paper The or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page I think this was a little menace on behalf of the workers, but was disguised as a suggestion of betterment. The workers continued by stating that since they were forced to back up and obey the Torahs ; it was merely just that they should hold the ability to make up ones mind on the devisings of the Torahs. ? We perform the responsibilities of the freewomans ; we must hold the privileges of freewomans. The workers believed that with cosmopolitan right to vote frequent elections were necessary. Possibly they felt that with authoritiess in office for a smaller sum of clip, this would discourage person from going to powerful. The thought of the elections was of import for the workers, because in the request they asked for unrestricted elections. These are elections that are non-threatening to both the campaigner every bit good as the elector. The workers were tired of holding people who did non understand them, speak for them. They wanted their ain people to stand up and talk on behalf of all the working category. The labors were non irrational in their demands. They knew that every adult male could non merely be allowed the right, to be a leader or a representative in the house. That is why they stated that every male of lawful age, sane head, and unconvicted of offense should be allowed the same rights as those in the higher categories. They besides suggested that voting be conducted in secret ballot signifier for the protection of those who vote. The biggest job with this request was that the demands were really of import, for both parties. It was hard for the higher categories to merely give up their rights, which, in their sentiments, were in the best custodies. However, the workers should hold had the rights that every other individual had. Possibly it was non wise of workers to be so rigorous in their demands, but with the defeat they felt, there was likely no other solution. It is interesting to look at the demands of the working category, because in today? s society these petitions are non that extreme. Most citizens are allowed all these voting rights and privileges, but at the clip of this national request it was really of import for the rights of the citizens to be recognized and heard.